Integrin‐mediated cell adhesion and subsequent cell spreading are essential for the growth and survival of many cell types. While integrin engagement is known to activate various signalling pathways, the role that cell spreading plays in the control of growth and survival is not clear. Using a novel technique, however, Chen et al.(1) demonstrate that the effect of cell spreading on growth and survival is not a consequence of increased area of contact with the extracellular matrix, supporting the hypothesis that regulation (...) through changes in cell tension and architecture play a key role. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Mimesis, Violence, and Socially Engaged Buddhism: Overture to a Dialogue Leo D. Lefebure University ofSaint Mary ofthe Lake René Girard's analysis ofdesire, mimetic rivalry, and the surrogate victim mechanism seeks to transform human consciousness in order to overcome seemingly intractable patterns ofrivalry and violence. In this project the Buddhist tradition, with its long commitment to nonviolence, its age-old suspicion of ordinary views of the self, and its ancient experience (...) of meditation as a transformative practice, exerts a claim to attention. The Buddhist tradition shares many of Girard's concerns: It denies the reality ofan autonomous, independent selfand calls attention to the interdependence ofall realities. It challenges its followers to become conscious ofthe sources oftheir own feelings and thoughts, to accept responsibility for them, and to be liberated from violence. Like Girard, Buddhism rejects the notion that there can be "good violence" as well as bad. For Buddhists, awakening from the illusions of the autonomous selfand freedom from violence are inseparable. The term, "Socially Engaged Buddhism," refers to a variety ofBuddhist move-ments since the 1950s which seek to apply ancient Buddhist principles to contemporary social, economic, and political problems. Powerful prejudices, however, threaten this conversation before it begins. Since the writings of Arthur Schopenhauer and Max Weber, Westerners have often seen Buddhism as a pessimistic religion, a worldnegating tradition that encourages the individual to withdraw from the world and seek a solitary salvation. The belief in karma has often been 122Leo D. Lefebure interpreted as fatalistic and inimical to social transformation. Buddhism, especially in the Mahayana traditions, has often accommodated to the dominant powers in society without exerting any effective social or political critique. Like every other major religious tradition, Buddhism has had an ambiguous history; and Westerners have often assumed prematurely that Buddhism has no history of social and political engagement whatsoever. Girard himself, in conversation with Jean-Claude Dussault in 1981, viewed Buddhism as a withdrawal from action in the world. Girard commented: Alors il me semble que la non-violence des religions orientales est la recherche d'une position hors de la violence, nirvana, etc., au prix de toute action. Mais cette recherche abandonne le monde en quelque sorte à lui-même. Alors il me semble que s'il fallait résumer d'un mot, ce serait un mot comme dégagement absolu par rapport à l'existence. ("Séminaire de recherche" 81) [It seems to me that the nonviolence of Eastern religions is the search for a position outside of violence, nirvana, etc., at the price ofall action. But this search abandons the world in a way to itself. Now it seems to me that if it were necessary to sum it up in a formula, it would be a phrase such as absolute détachement in regard to existence.] Later in the conversation, Girard expressed his own negative reaction: "Si vous voulez, je me sens profondément gréco-biblico-occidental face à ce renoncement nirvanesque total." (83) [If you please, I feel myself profoundly greco-biblical-occidental in contrast to this complete nirvanesque renunciation.] According to Girard's interpretation, Buddhism offers no constructive solution to the social problems ofrivalry and violence, but only an individual escape through withdrawal. Closely related to Girard's negative view ofBuddhism is his interpretation ofall non-biblical religions as channeling violence but as powerless to break the cycle ofviolence. He claims that only biblical revelation offers a basis for overcoming the violence of the surrogate victim mechanism: "To recognize Christ as God is to recognize him as the only being capable of rising above the violence that had, up to that point, absolutely transcended mankind. Violence is the controlling agent in every form ofmythic or cultural structure, and Christ is the only agent who is capable of escaping from these structures and freeing us from their dominance" (1987, Mimesis, Violence, and Socially Engaged Buddhism 123 219). Girard asserts that there is no common ground between the violenceridden mythologies which dominate all other religions and the revelation of God in Christianity (1986, 166). Girard is almost Barthian in his exclusivistic claims for Christian revelation, viewing all other religions as products of human mimetic striving and only Christianity as the true... (shrink)

We examine the influence of social capital in the municipal bond market. Defined as the norms and networks that encourage cooperation, social capital is a social construct which captures a region’s level of altruism, trustworthiness, and propensity to honor obligations. We expect that municipalities with high social capital are more trustworthy and likely to honor their debt obligations, which will result in lower bond yields. Our findings confirm that the bonds issued by municipalities located in high social capital counties exhibit (...) lower yields compared to the municipalities located in low social capital counties. Our findings are also supported by bond prices in the secondary market, which shows that bonds from the municipalities located in high social capital regions have higher prices. Additional tests reveal that the influence of social capital is stronger for general obligation bonds, suggesting that social capital matters more for bonds where the willingness of municipalities to pay taxes is an important factor. Lastly, we document that the bonds of municipalities in high social capital areas are less likely to have insurance, suggesting that social capital may act as a substitute for bond insurance. (shrink)

Includes translations of the important manuscripts in silk found at the famous Mawangdui Tomb in 1973.

Context The attitudes of medical professionals towards physician assisted dying have been widely discussed. Less explored is the level of agreement among physicians on the possibility of ‘rational suicide’—a considered suicide act made by a sound mind and a precondition of assisted dying legislation. Objective To assess attitudes towards rational suicide in a representative sample of senior doctors in England and Wales. Methods A postal survey was conducted of 1000 consultants and general practitioners randomly selected from a commercially available database. (...) The main outcome of interest was level of agreement with a statement about rational suicide. Results The corrected participation rate was 50%; 363 questionnaires were analysed. Overall 72% of doctors agreed with the possibility of rational suicide, 17% disagreed, and 11% were neutral. Doctors who identified themselves as being more religious were more likely to disagree. Some doctors who disagreed with legalisation of physician assisted suicide nevertheless agreed with the concept of rational suicide. Conclusions Most senior doctors in England and Wales feel that rational suicide is possible. There was no association with specialty. Strong religious belief was associated with disagreement, although levels of agreement were still high in people reporting the strongest religious belief. Most doctors who were opposed to physician assisted suicide believed that rational suicide was possible, suggesting that some medical opposition is best explained by other factors such as concerns of assessment and protection of vulnerable patients. (shrink)

Reciprocal altruism involves foregoing an immediate benefit for the sake of a greater long-term reward. It follows that individuals who exhibit a stronger preference for future over immediate rewards should be more disposed to engage in reciprocal altruism – in other words, ‘patient’ people should be more cooperative. The present study tested this prediction by investigating whether participants’ contributions in a public-good game correlated with their ‘discount rate’. The hypothesis was supported: patient people are indeed more cooperative. The paper discusses (...) alternative interpretations of this result, and makes some suggestions for future research. (shrink)

To the evolutionarily oriented clinical psychiatrist, the discipline of behavioural ecology is a fertile basic science. Human psychology discusses variation in terms of means, standard deviations, heritabilities, and so on, but behavioural ecology deals with mutually incompatible alternative behavioural strategies, the heritable variation being maintained by negative frequency-dependent selection. I suggest that behavioural ecology should be included in the interdisciplinary dialogue recommended by Keller & Miller (K&M). (Published Online November 9 2006).

Stalking is a pattern of behavior over time in which a stalker seeks to gain access to, or control over, an unwilling victim. Such actions range from the benign to the malicious and may cause emotional distress or harm to the victim. With the widespread adoption of new technologies, new forums of Internet-mediated discourse now exist which offer stalkers unprecedented scope to locate and exert influence over victims. Cyberstalking, the convergence of stalking and cyberspace, has created new challenges for the (...) prevention, detection, and prosecution of this new phenomenon as the traditional methods of detection by witnesses and enforcement through physical restraining orders often are inadequate.In this paper we suggest a cryptographic approach for tracking cyberstalkers. We first define the threat model in terms of the profile of a cyberstalker, as well as legal and law enforcement constraints. We then describe a monitoring system that addresses the basic admissibility requirements of our threat model, by capturing and verifying circumstantial evidence for use in cyberstalking investigations. (shrink)

This is a comprehensive reference source on 18th-century authors writing in the English language about philosophical ideas and issues. It features authors taken from 1689 through to the mid-19th century, the period beginning with John Locke and ending with Dugald Stewart. The word philosophical is used in a wide, 18th-century sense. Therefore, the Dictionary includes epistemology, ethics, aesthetics, education, politics, rhetoric, science, medicine, biology, geology, chemistry and theology.

BackgroundThere is increasing need for peer reviewers as the scientific literature grows. Formal education in biostatistics and research methodology during residency training is lacking. In this pilot study, we addressed these issues by evaluating a novel method of teaching residents about biostatistics and research methodology using peer review of standardized manuscripts. We hypothesized that mentored peer review would improve resident knowledge and perception of these concepts more than non-mentored peer review, while improving review quality.MethodsA partially blinded, randomized, controlled multi-center study (...) was performed. Seventy-eight neurology residents from nine US neurology programs were randomized to receive mentoring from a local faculty member or not. Within a year, residents reviewed a baseline manuscript and four subsequent manuscripts, all with introduced errors designed to teach fundamental review concepts. In the mentored group, mentors discussed completed reviews with residents. Primary outcome measure was change in knowledge score between pre- and post-tests, measuring epidemiology and biostatistics knowledge. Secondary outcome measures included level of confidence in the use and interpretation of statistical concepts before and after intervention, and RQI score for baseline and final manuscripts.ResultsSixty-four residents (82%) completed initial review with gradual decline in completion on subsequent reviews. Change in primary outcome, the difference between pre- and post-test knowledge scores, did not differ between mentored (−8.5%) and non-mentored (−13.9%) residents (p = 0.48). Significant differences in secondary outcomes (using 5-point Likert scale, 5 = strongly agree) included mentored residents reporting enhanced understanding of research methodology (3.69 vs 2.61; p = 0.001), understanding of manuscripts (3.73 vs 2.87; p = 0.006), and application of study results to clinical practice (3.65 vs 2.78; p = 0.005) compared to non-mentored residents. There was no difference between groups in level of interest in peer review (3.00 vs 3.09; p = 0.72) or the quality of manuscript review assessed by the Review Quality Instrument (RQI) (3.25 vs 3.06; p = 0.50).ConclusionsWe used mentored peer review of standardized manuscripts to teach biostatistics and research methodology and introduce the peer review process to residents. Though knowledge level did not change, mentored residents had enhanced perception in their abilities to understand research methodology and manuscripts and apply study results to clinical practice. (shrink)

By constructing a maximal incomplete d.r.e. degree, the nondensity of the partial order of the d.r.e. degrees is established. An easy modification yields the nondensity of the n-r.e. degrees and of the ω-r.e. degrees.

This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)

By constructing a maximal incomplete d.r.e. degree, the nondensity of the partial order of the d.r.e. degrees is established. An easy modification yields the nondensity of the n-r.e. degrees and of the ω-r.e. degrees.

The Voices of Liberation series celebrates the lives and writings of African Liberation activists and heroes. By providing access to the thoughts and writings of some of the many men and women who fought for the dismantling of apartheid, this series invites the contemporary reader to engage directly with the rich history of the struggle for democracy, to discover where we come from and to explore how we, too, can choose to shape our destiny.

Although Charles S. Peirce, strictly speaking, never formulated a ‘full-blown’ normative theory—a single over-all architectonic system—we believe that there lies within his work a valuable sketch of the ideal for feeling, action, and thought, and how this ideal should be followed, and in connection to this, Peirce offered a model for rational behaviour, including self-control. In the following essay we will try, modestly, to draw a rough outline of this sketch. Firstly, we will focus on the three normative sciences, their (...) relationship and their task of finding out how feeling, action and thought ought to be controlled. Then, we will take a look at the sign-universe. The very universe is a sign-universe and within this evolutionary universe feeling, matter and thought incessantly melt together into ‘concrete reasonableness’; according to Peirce, rendering the world more reasonable. This is the Summum Bonum that man can and indeed should pursue. Hence it makes absolutely no sense to speak of the three normative sciences out of this metaphysical or cosmological context. Finally, we will try to see in what way rationality can be said to fall within the spheres of self-control, bearing in mind that self-control is directly related to conditional purpose. (shrink)